Ordinary Academicians

Rafael A. Radi Isola

Prof. Dr.

Rafael A. Radi Isola

Date of birth 07 May 1963

Place Montevideo, Uruguay (America)

Nomination 07 November 2023

Field Biochemistry

Title Professor and Chairman, Department of Biochemistry

  • Biography
  • Publications

My primary research interests are in biomedicine and biochemistry, focusing on the  molecular basis of disease and aging in humans. In particular, I concentrated research efforts in the areas on oxidative and nitric oxide metabolism, mitochondrial function, post-translational modification of proteins and  mechanisms of cell degeneration and death, with a discovery path that involves interdisciplinary approaches. My contributions have unraveled molecular mechanisms of chronic diseases and assisted to the design and development of therapeutics. Also, my work has contributed to understand oxidative cellular immune responses to invading pathogens and revealed the role of microbial antioxidant systems as virulence factors.

Ten selected publications from a total of 340, H-index = 95 (web of science)

  1. Piacenza L, Zeida A, Trujillo M, Radi R. The superoxide radical switch in the biology of nitric oxide and peroxynitrite. Physiol Rev. doi: 10.1152/physrev.00005.2022. Epub ahead of print. PMID: 35605280, 2022
  2. Piacenza L, Trujillo M, Radi R. Reactive species and pathogen antioxidant networks during phagocytosis. J Exp Med. 4;216(3):501-516, 2019
  3. Radi R. Oxygen Radicals, Nitric Oxide and Peroxynitrite: Redox Pathways in Molecular Medicine. Proc Natl Acad Sci U S A. 115(23):5839-5848, 2018
  4. Ferrer-Sueta G, Campolo N, Trujillo M, Bartesaghi S, Romero N, Alvarez R and Radi R. Biochemistry of Peroxynitrite and Protein Tyrosine Nitration. Chem. Rev. 118(3):1338-1408, 2018
  5. Hannibal L, Tomasina F, Capdevila DA, Demicheli V, Tórtora V, Alvarez-Paggi D, Jemmerson R, Murgida DH, Radi R. Alternative Conformations of Cytochrome c: Structure, Function, and Detection. Biochemistry. 55(3):407-28, 2016. 
  6. Radi R. Peroxynitrite, a stealthy biological oxidant. J. Biol. Chem. 13;288(37):26464-72. 2013
  7. Szabó C, Ischiropoulos H and Radi R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nature Reviews Drug Discovery. 6: 662-680, 2007.
  8. Radi R. Nitric oxide, oxidants and protein tyrosine nitration. Proc. Natl. Acad. Sci. USA. 101, 4003-4008, 2004.
  9. Radi R, Peluffo G, Alvarez M N, Naviliat M and Cayota A.  Unraveling peroxynitrite formation in biological systems. Free Radical Biol Med. 30, 463-488, 2001.
  10. Radi R, Beckman J S, Bush K M and Freeman B A.  Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide. J. Biol. Chem. 266: 4244-4250, 1991. [Selected as JBC Classic, Jan 2016]

Professional Address

Departamento de Bioquímica
Facultad de Medicina
Universidad de la República
Avda. General Flores 2125
11800 Montevideo, Uruguay