Chien-Jen Chen

chienjenchen2021

Luogo di nascita Kaohsiung, Taiwan (ROC)
Nomina 20 aprile 2021
Disciplina Epidemiologia, Salute pubblica e Genetica umana
Titolo Distinguished Professor; ex Vice Presidente di Taiwan (ROC) (2016-2020); ex Vice President, Academia Sinica (2011-2015)

Principali premi, riconoscimenti e accademie
Fellowships: Overseas Fellow, American College of Epidemiology, 1989; Fogarty International Research Fellow, US National Institute of Health, 1989; Fellow, American College of Epidemiology, 1993; Outstanding Scholar, Foundation for Outstanding Scholarship, Taiwan, 1995-1999; Outstanding Research Fellow, National Science Council, Taiwan, 2003. Accademie: Accademico, Academia Sinica, Taiwan, 1998; Membro, World Academy of Sciences, 2005; Membro onorario, Accademia delle Scienze della Mongolia, 2007; Membro internazionale, US National Academy of Sciences, 2017. Onoreficenze: National Chair Professor, Ministero dell'Istruzione, Taiwan, 1997-2002; Honorary Doctor of Philosophy Degree, China Medical University, Taiwan, 2014; Honorary Doctor of Philosophy Degree, Kaohsiung Medical University, Taiwan, 2020; Honorary Doctor of Science Degree, National Sun Yet-Sen University, Taiwan, 2020. Awards: Outstanding Research Award, National Science Council, Taiwan, 1986-1996; Medical Research Award, Ching-Hsing Medical Foundation, Taiwan, 1990; Outstanding Teaching Award, Ministry of Education, Taiwan, 1992; Medical Research Award, United Medical Foundation, Taiwan, 1992; Academic Award, Ministry of Education, Taiwan, 1997; ISI Citation Classic Award, ISI Thomas Scientific, USA, 2001; Garland W. Clay Award, American Academy of Optometry, USA, 2003; Presidential Science Prize, Taiwan, 2005; Science and Engineering Achievement Award, US Taiwanese-American Foundation, 2009; Outstanding Merit Award, Wang Ming-Ning Memorial Foundation, Taiwan, 2010; Knowledge for the World Award, Johns Hopkins University, USA, 2012; Outstanding Achievement Award in Science and Technology, Taiwan, 2013. Medaglie e ordini: Achievement Medal (First Class), Executive Yuan, Taiwan, 2005; Health Medal (First Class), Department of Health, Taiwan, 2005; Officier dans l’Ordre des Palmes Academiques, Ministry of Education, France, 2009; Knight, Equestrian Order of the Holy Sepulchre of Jerusalem, Vatican, 2010; Science Profession Medal (First Class), National Science Council, Taiwan, 2012; Cavaliere, Pontificio Ordine Equestre di San Gregorio Magno, Vaticano, 2013; Distinguished Service Medal (First Class), Academia Sinica, Taiwan, 2016; Order of Dr. Sun Yat-sen with Grand Cordon, Ufficio del Presidente, Taiwan, 2020

Riassunto dell'attività scientifica
Il Prof. Chen ha scoperto molteplici rischi per la salute e la suscettibilità acquisita e genetica a causa dell'avvelenamento cronico da arsenico, che ha portato alla consapevolezza globale e alla mitigazione di questa grande calamità ambientale attraverso il consumo di acqua potabile ad alto contenuto di arsenico. Inoltre, Chen ha individuato i fattori di previsione del rischio per quei tumori causati da virus, in modo da poterne derivare degli utili calcolatori di rischio. Chen ha aperto la strada al paradigma della carica virale nella progressione patologica dell'epatite virale e ha verificato l'efficacia del primo vaccino antitumorale, che ha portato all'uso di vaccini e antivirali/antibiotici per prevenire i tumori correlati alle infezioni.

Pubblicazioni principali
Si riportano le dieci pubblicazioni più rappresentative del Prof. Chen: C.J. Chen, Y.C. Chuang, T.M. Lin and H.Y. Wu, Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: High-arsenic artesian well water and cancers, Cancer Res., 45, 5895-9 (1985); C.J. Chen, T.L. Kuo and M.M. Wu, Arsenic and cancers (letter), Lancet, 1, 414-5 (1988); M.M. Wu, T.L. Kuo, Y.H. Hwang and C.J. Chen, Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases, Am. J. Epidemiol., 130, 1123-32 (1989); C.J. Chen, C.W. Chen, M.M. Wu and T.L. Kuo, Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water”, Brit. J. Cancer, 66, 888-92 (1992); M.H. Chang, C.J. Chen, M.S. Lai, M.S. Kong, T.C. Wu, D.C. Liang, H.M. Hsu, W.Y. Shau, D.S. Chen and Taiwan Childhood Hepatoma Study Group, Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children, New Engl. J. Med., 336, 1855-59 (1997); Y.C. Chien, J.Y. Chen, M.Y. Liu, H.I. Yang, M.M. Hsu, C.J. Chen and C.S. Yang, Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men, New Engl. J. Med., 345, 1877-82 (2001); H.I. Yang, S.N. Lu, S.L. You, C.A. Sun, L.Y. Wang, K. Hsiao, P.J. Chen, D.S. Chen, Y.F. Liaw and C.J. Chen, Hepatitis B e antigens and the risk of hepatocellular carcinoma, New Engl. J. Med., 347, 168-74 (2002); U.H. Iloeje, H.I. Yang, J. Su, C.L. Jen, S.L. You and C.J. Chen, Predicting cirrhosis risk based on the level of circulating hepatitis B viral load, Gastroenterology, 130, 678-686 (2006); C.J. Chen, H.I. Yang, J. Su, C.L. Jen, S.L. You, S.N. Lu, G.T. Huang and U.H. Iloeje, Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level, JAMA-J. Am. Med. Assoc., 295, 65-73 (2006); H.I. Yang, M.F. Yuen, H.L. Chan, K.H. Han, P.J. Chen, D.Y. Kim, S.H. Ahn, C.J. Chen, V.W. Wong, and W.K. Seto, Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score. Lancet Oncol., 12, 568-74 (2011).

Professional Address

Academia Sinica
Genomics Research Center
No. 128 Academia Road Section 2
Nankang, Taipei 11529
Taiwan (ROC)