Manfred Eigen

eigen2010

Date of Birth 9 May 1927
Place Bochum (Germany)
Nomination 12 May 1981
Field Physical Chemistry
Title Professor, Nobel laureate in Chemistry, 1967

Most important awards, prizes and academies
Awards: Nobel Prize in Chemistry (1967); Otto-Hahn-Prize; Linus Pauling Medal; Carus Medal; Palmes Académiques; Ordre pour le mérite; Paul Ehrlich/Ludwig Darmstädter Prize; Paracelsus Medal; Keilin Medal; Faraday Medal; Helmholtz Medal; Diesel Medal, Küpfmüller Ring. Honorary Degrees: Washington (St. Louis), Harvard, Chicago, Nottingham, Jerusalem, Hull, Bristol, Cambridge, Debrecen, München, Bielefeld, Utah, Alicante. Academies: Deutsche Akademie der Naturforscher, Halle; Akademie der Wissenschaften, Göttingen; Bayerische Akademie der Wissenschaften, München; Berlin-Brandenburgische Akademie der Wissenschaften; Honorary member, Österreichische Akademie der Wissenschaften; Royal Society, London; Honorary member, Weizmann Institute of Sciences; Royal Danish Academy of Sciences; Institut de France, Paris; Académie Royale de Belgique; Honorary member, Hungarian Academy of Sciences; Pontifical Academy of Sciences; Russian Academy of Sciences; American Philosophical Society, Philadelphia; National Academy of Sciences, USA; American Academy of Arts and Sciences; Honorary member, New York Academy of Sciences; Honorary member, European Academy of Arts and Sciences.

Summary of scientific research
The mechanisms of biochemical reactions (enzyme kinetics, code reading, biopolymerization); the origins and evolution of life (theory and experiments); evolutionary biotechnology.

Main publications
Eigen, M., Über die Kinetik sehr schnell verlaufender Ionenreaktionen in wässriger Lösung,Z. phys. Chem. N.F., 1, p. 176 (1954); Eigen, M., Methods for Investigation of Ionic Reactions in Aqueous Solutions with Half Times as Short as 10-9 sec., Disc. Farad. Soc., 17, p. 194 (1954); Eigen, M., Proton Transfer, Acid-Base Catalysis, and Enzymatic Hydrolysis, Angew. Chem. Intern. Ed., 3, pp. 1-19 (1964); Eigen, M., Kinetics of reaction control and information transfer in enzymes and nucleic acids. Nobel Symp. 5 on Fast Reactions and Primary Processes, Chem. Kinetics (Stig Claesson, ed.), Almquist & Wiksell, Stockholm, Intersci. Publ., p. 333 (1968); Eigen, M., Die "unmeßbar" schnellen Reaktionen Nobelvortrag, Les Prix Nobel en 1967, p. 151 (1968); Eigen, M., Selforganization of Matter and the Evolution of Biological Macromolecules, Naturwissenschaften, 58, p. 465 (1971); Eigen, M., Das Spiel – Naturgesetze steuern den Zufall, Piper-Verlag, München 1975 (with Winkler-Oswatitsch, R.), Laws of the Game – How the Principles of Nature Govern Chance, Alfred A. Knopf (New York, 1981) (with Winkler-Oswatitsch, R.); Eigen, M., The Hypercycle, "A Principle of Natural Self-Organization", Naturwissenschaften, 64, pp. 541-65 (1977), 65, pp. 7-41 and 65, pp. 341-69 (1978) (with Schuster, P.); Eigen, M., Die Kunst zu Titrieren. Vom klassischen Endpunktverfahren zur modernen differentiellen und dynamischen Analyse, Angew. Chem., 91, pp. 20-51 (1979) (with Winkler-Oswatitsch, R.); Eigen, M., Evolutionary Molecular Engineering Based on RNA Replication, Pure & Appl. Chem., 56, pp. 967-978 (1984) (with Gardiner, W.); Eigen, M., Stufen zum Leben. Die frühe Evolution im Visier der Molekularbiologie, R. Piper-Verlag, München (1987), Steps towards Life, A Perspective on Evolution, Oxford University Press (Oxford, 1992), pp. 173 (with Winkler-Oswatitsch, R.); Eigen, M., The Molecular Quasispecies, Adv. Chem. Phys., 75, Ch. 4, pp. 149-263 (1987) (with McCaskill, J.S. and Schuster, P.); Eigen, M., Sequence Space and Quasispecies Distribution, RNA Genetic (Domingo, E., Holland, J.J. und Ahlquist, P., Hrsg.), vol. III, Variability of RNA Genomes, pp. 211-45, CRC Press, Boca Raton, FL (1988) (with Biebricher, C.K.); Eigen, M., Statistical Geometry in Sequence Space: A Method of Quantitative. Comparative Sequence Analysis, Proc. Natl. Acad. Sci. USA, 85, pp. 5913-7 (1988) (with Winkler-Oswatitsch, R. and Dress, A.); Eigen, M.,Perspektiven der Wissenschaften, Deutsche Verlagsanstalt, Stuttgart, p. 288, S. (1988); Eigen, M., How Old Is the Genetic Code? Statistical Geometry of tRNA Provides an Answer, Science, 244, pp. 673-9 (1989) (with Lindemann, B.F., Tietze, M., Winkler-Oswatitsch, R., Dress, A. and von Haeseler, A.); Eigen, M., The Hypercycle, Coupling of RNA and Protein Biosynthesis in the Infection Cycle of an RNA Bacteriophage, Biochem., 10, pp. 11005-18 (1991) (with Biebricher, C.K., Gebinoga, M. and Gardiner, W.C.); Eigen, M., The Fifth Paul Ehrlich Lecture, Virus Strains as Models of Molecular Evolution, Medicin. Res. Rev., 13, pp. 385-9 (1993); Eigen, M., Sorting single molecules: Application to diagnostic and evolutionary biotechnology, Proc. Natl. Acad. Sci. USA, 91, pp. 5740-7 (1994) (with Rigler, R.); Eigen, M., Quasispecies: The concept and the word, Molecular Basis of Viral Evolution (A. Gibbs, C.H. Calisher, eds.), pp. 181-91, Cambridge University Press, Cambridge (1995) (with Domingo, E., Holland, J., Biebricher, C.); Eigen, M., Die 'unmeßbar' schnellen Reaktionen. Frühe Arbeiten (1954-1967). Mit einem Vorw. und Einf. von R. Winkler-Oswatitsch. Ostwalds Klassiker der exakten Wissenschaften Band 281, Verlag Harri Deutsch, Frankfurt am Main (1996); Eigen, M., Detection of HIV-1 RNA by nucleic acid sequence-based amplification com bined with fluorescence correlation spectroscopy, Proc. Natl. Acad. Sci. USA, 93, pp. 12811-6 (1995) (with Oehlenschläger, F. and Schwille, P.); Eigen, M., Prionics or the kinetic basis of prion diseases, Biophysical Chemistry, 63, (1996) A1-A18 – M. Eigen; Eigen, M., Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: High throughput screening for enzyme activity, Proc. Natl. Acad. Sci. USA, 95, pp. 1421-6 (1998) (Koltermann, A., Kettling, U., Bieschke, J., Winkler, T., Eigen, M.); Eigen, M., BSE und das Prionen-Problem, Spektrum der Wissenschaft, 4, pp. 40-9 (2001).

Professional Address

Max-Planck-Institut für biophysikalische Chemie
Postfach 2841
D-37018 Göttingen-Nikolausberg (Germany)