Robert Eric Betzig

betzig2016

Date of Birth 13 January 1960
Place Ann Arbour, Michigan, USA
Nomination 31 May 2016
Field Chemistry
Title Nobel laureate in Chemistry, 2014

Most important prizes, awards and academies
1992 William L. McMillan Award; 1993 National Academy of Sciences Award for Initiatives in Research; 2014 Nobel Prize in Chemistry; 2015 Honorary Fellow, Royal Society of Chemistry; 2015 Member, National Academy of Sciences; 2015 Newcomb Cleveland Prize.

Summary of scientific research
Near-field optics and application to biology, data storage, and semi-conductor spectroscopy. Developed superresolution method based on multidimensional localization. Developed optical lattice microscopy, photoactivated localization microscopy.

Main publications
E. Betzig, “Experiments on the linear and non-linear evolution of the double helical instability in jets”, Proc. of the 19th Annual Meeting of the American Institute of Aeronautics and Astronautics (1981); E. Betzig, A. Lewis, A. Harootunian, M. Isaacson, and E. Kratschmer, “Near-field scanning optical microscopy (NSOM): development and biophysical applications”, Biophys. J. 49, 269 (1986); E. Betzig, A. Harootunian, A. Lewis, and M. Isaacson, “Near-field diffraction by a slit: implications for superresolution microscopy”, Appl. Opt. 25, 1890 (1986); A. Harootunian, E. Betzig, M. Isaacson, and A. Lewis, “Superresolution fluorescence near-field scanning optical microscopy”, Appl. Phys. Lett. 49, 674 (1986); M. Isaacson, E. Betzig, A. Harootunian, and A. Lewis, “Scanning optical microscopy at tenth wavelength resolution using near-field imaging methods”, Ann. N. Y. Acad. Sci. 483, 448 (1986); E. Betzig, M. Isaacson, A. Lewis, and K. Lin, “Near-field scanning optical microscopy”, Proc. 45th Annual Meeting of the Electron Microscopy Society of America, G.W. Bailey, Ed., 184 (1987); E. Betzig, M. Isaacson, and A. Lewis, “Collection mode near-field scanning optical microscopy”, Appl. Phys. Lett. 51, 2088 (1987); A. Lewis, E. Betzig, A. Harootunian, M. Isaacson, and E. Kratschmer, “Near-field imaging of fluorescence”, in Spectroscopic Membrane Probes, Vol. II L.M. Loew, Ed., 81 (CRC Press, 1988); E. Betzig, M. Isaacson, H. Barshatzky, A. Lewis, and K. Lin, “Near-field scanning optical microscopy (NSOM)”, Proc. Soc. Photo-Opt. Instrum. Eng. 897, 91 (1988); E. Betzig, M. Isaacson, H. Barshatzky, A. Lewis, and K. Lin, “Superresolution imaging with near-field scanning optical microscopy (NSOM)”, Ultramicroscopy 25, 155 (1988); E. Betzig, J.K. Trautman, T.D. Harris, J.S. Weiner, and R.L. Kostelak, “Breaking the diffraction barrier: optical microscopy with nanometric resolution”, Science 251, 1468 (1991); E. Betzig, P.L. Finn and J.S. Weiner, “Combined shear force and near-field scanning optical microscopy”, Appl. Phys. Lett. 60, 2484 (1992); J.K. Trautman, E. Betzig, J.S. Weiner, D.J. DiGiovanni, T.D. Harris, F. Hellman, and E.M. Gyorgy, “Image contrast in near-field optics”, J. Appl. Phys. 71, 4659 (1992); E. Betzig, J.K. Trautman, J.S. Weiner, T.D. Harris, and R. Wolfe, “Polarization contrast in near-field scanning optical microscopy”, Appl. Opt. 31, 4563 (1992); E. Betzig, J.K Trautman, R. Wolfe, E.M. Gyorgy, P.L. Finn, M.H. Kryder, and C.-H. Chang, “Near-field magneto-optics and high density data storage”, Appl. Phys. Lett. 61, 142 (1992); E. Betzig and J.K. Trautman, “Near-field optics: microscopy, spectroscopy, and surface modification beyond the diffraction limit”, Science 257, 189 (1992); E. Betzig, “Principles and applications of near-field scanning optical microscopy”, in Near-Field Optics, D.W. Pohl and D. Courjon, Eds., 7 (Kluwer, Dordrecht, 1993); E. Betzig and R.J. Chichester, “Single molecules observed by near-field scanning optical microscopy”, Science 262, 1422 (1993); E. Betzig, S.G. Grubb, R.J. Chichester, D.J. DiGiovanni, and J.S. Weiner, “Fiber laser probe for near-field scanning optical microscopy”, Appl. Phys. Lett. 63, 3550 (1993); E. Betzig, R.J. Chichester, F. Lanni, and D.L. Taylor, “Near-field fluorescence imaging of cytoskeletal actin”, Bioimaging 1, 129 (1993); R.D. Grober, T.D. Harris, J.K. Trautman, and E. Betzig, “Design and implementation of a low temperature near-field scanning optical microscope”, Rev. Sci. Instrum. 65, 626 (1994); R.D. Grober, T.D. Harris, J.K. Trautman, E. Betzig, W. Wegscheider, L. Pfeiffer, and K. West, “Optical spectroscopy of a GaAs/AlGaAs quantum wire structure using near-field scanning optical microscopy”, Appl. Phys. Lett. 64, 1421 (1994); J.K. Trautman, J.J. Macklin, L.E. Brus, and E. Betzig, “Near-field spectroscopy of single molecules at room temperature”, Nature 369, 40 (1994); H.F. Hess, E. Betzig, T.D. Harris, L.N. Pfeiffer, and K.W. West, “Near-field spectroscopy of the quantum constituents of a luminescent system”, Science 264, 1740 (1994); S.K. Buratto, J.W.P. Hsu, J.K. Trautman, E. Betzig, R.B. Bylsma, C.C. Bahr, and M.J. Cardillo,“Imaging InGaAsP quantum well lasers using near-field scanning optical microscopy”, J. Appl. Phys. 76, 7720 (1994); S.K. Buratto, J.W.P. Hsu, J.K. Trautman, E. Betzig, R.B. Bylsma, C.C. Bahr, and M.J. Cardillo, “Near-field photoconductivity: Application to carrier transport in InGaAsP quan- tum well lasers”, Appl. Phys. Lett. 65, 2654 (1994); E. Betzig, “Proposed method for molecular optical imaging”, Opt. Lett. 20, 237 (1995); J. Hwang, L.K. Tamm, C. Bohm, T.S. Ramalingam, E. Betzig, and M. Edidin, “Nanoscale complexity of phospholipid monolayers investigated by near-field scanning optical microscopy”, Science 270, 610 (1995); L.K. Tamm, C. Bohm, J. Yang, Z.F. Shao, J. Hwang, M. Edidin, and E. Betzig, “Nanostructure of supported phospholipid monolayers and bilayers by scanning probe microscopy”, Thin Solid Films 285, 813 (1996); G. Merritt, E. Monson, E. Betzig, and R. Kopelman, “A compact fluorescence and polarization near-field scanning optical microscope”, Rev. Sci. Instrum. 69, 2685 (1998); E. Betzig, “Excitation strategies for optical lattice microscopy”, Opt. Express 13, 3021 (2005); E. Betzig, “Sparse and composite coherent lattices”, Phys. Rev. A. 71, 063406 (2005); E. Betzig, G.H. Patterson, R. Sougrat, O.W. Lindwasser, S. Olenych, J.S. Bonifacino, M.W. Davidson, J. Lippincott-Schwartz, H.F. Hess, “Imaging intracellular fluorescent proteins at nanometer resolution”, Science 313, 1642 (2006); H. Shroff, C.G. Galbraith, J.A. Galbraith, H. White, J. Gillette, S. Olenych, M.W. David- son, E. Betzig, “Dual color superresolution imaging of genetically expressed probes within individual adhesion complexes”, Proc. Natl. Acad. Sci. 104, 20308 (2007); N. Ji, J.C. Magee, E. Betzig, “High speed, low photodamage nonlinear imaging using passive pulse splitters”, Nat. Methods 5, 197 (2008); S. Manley, J.M. Gillette, G.H. Patterson, H. Shroff, H.F. Hess, E. Betzig, J. Lippincott- Schwartz, “High density mapping of single molecule trajectories with photoactivated localization microscopy”, Nat. Methods 5, 155 (2008); H. Shroff, C.G. Galbraith, J.A. Galbraith, E. Betzig, “Live cell photoactivated localization microscopy of nanoscale adhesion dynamics”, Nat. Mathods 5, 417 (2008); H. Shroff, H. White, E. Betzig, “Photoactivated localization microscopy (PALM) of adhesion complexes”, Curr. Protoc. Cell Biol. 41, 4.21.1 (2008); N. Ji, H. Shroff, H.N. Zhong, E. Betzig, “Advances in the speed and resolution of light microscopy”, Curr. Opin. Neurobiol. 18, 605 (2008); D. Greenfield, A.L. McEvoy, H. Shroff, G.E. Crooks, N.S. Wingreen, E. Betzig, J. Liphardt, “Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy”, PLoS Biol. 7, e1000137 (2009); D. Li, L. Shao, B. Chen, X. Zhang, M. Zhang, B. Moses, D.E. Milkie, J.R. Beach, J.A. Hammer, M. Pasham, T. Kirchhausen, M.A. Baird, M.W. Davidson, P. Xu, E. Betzig, “Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics”, Science 349, aab3500 (2015); N. Yamashita, M. Morita, W.R. Legant, B. Chen, E. Betzig, H. Yokota, Y. Mimori-Kiyosue, “Three-dimensional tracking of plus-tips by lattice light-sheet microscopy permits the quantification of microtubule growth trajectories within the mitotic apparatus”, J. Biomed. Opt. 20,101206 (2015); J. Xie, M. Wooten, V. Tran, B. Chen, C. Pozmanter, C. Simbolon, E. Betzig, X. Chen, “Histone H3 Threonine Phosphorylation Regulates Asymmetric Histone Inheritance in the
Drosophila Male Germline”, Cell 163, 920 (2015).

Professional address

Janelia Research Campus
Howard Hughes Medical Institute
19700 Helix Drive
Ashburn, VA 20147
USA